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Thursday, October 6, 2022

Scientists Tried To Overdose On Marijuana In Monkeys With 9000mg Of THC, They All Lived But They Were ‘Too Stoned’

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Have you ever wondered how consumables and medicines are tested around the world before humans try them? The answer to this is rodents and other mammals.

Advances in cannabis research are largely due to findings about the drug’s effects on animals such as dogs, rats, and monkeys. For a drug like cannabis to reach the clinical trial stage, it must be approved. The risks involved are reduced when it is discovered that the drug has few negative effects on experimental animals.

In this research by cannabis scientists, we can say conclusively that rats and excessive amounts of THC have no action together. On the other hand, monkeys can tolerate a high dose of the psychoactive compound.

Experimental use of animals in cannabis research

Animals, especially rodents, are regularly used in various laboratory studies. Ethics guide the experimental use of animals to ensure that all experiments remain reasonable.

In cannabis research, only animals with endocannabinoid systems are used. The scientists observed that the mice functionally expressed endocannabinoid systems that can be affected by cannabinoids in marijuana. Although uniquely engineered CB receptors have been found they cannot tolerate as much THC as primates.

Using animals, the potential risks of marijuana medications, as well as their side effects and ECS breakdown mechanism They can be known and reduced before being introduced to humans in clinical trials. These animals are often used to assess the effectiveness of new or modified drugs, as well as to assess the risks of cannabis addiction.

These animals were used because they have DNA similar to humans, especially rhesus monkeys. Which is 97-99% similar to humans. Recent research has observed that squirrel monkeys, when given unrestricted access to cannabis, display brain reactions and behavior similar to those observed in humans.

This indicates that monkeys are best suited for cannabis research. However, this does not eliminate the use of mice and other animals which can still help shed light on these studies. These young animals are easily accessible and inexpensive to purchase and care for during the study period. During the experiment, at least two generations of mice or mice will be observed due to their short life span. Also, its unsightly nature makes it safer to use. Ethics pose less of a moral quandary over the use of small animals.

The findings

The publication “Comparing the acute oral toxicity of cannabis in rats, dogs and monkeys” revealed the effects of cannabis after administration of excessive doses of THC in the diets of rats, dogs and monkeys. This research has been in the works since 1973 when the Mason Research Institute in Worcester, Massachusetts first worked on it. The aim of the experiment was to determine what might be called a “lethal dose” of THC in mammals, as well as its severe effects.

Search overview

The experiment used delta-8 THC and Delta 9 THC, as well as raw marijuana extract (CME). Raw marijuana extract contains delta-9 THC in large amounts and a significant amount of CBNAnd Convention on Biological Diversity, And Delta 8 THC. Medicines were introduced to animals orally through the fattening process.

Research results

The study was more or less culling of the rats involved. 95% of the total employed population died. None of the monkeys died, although they appeared to be severely stoned.

Rats

373 Wistar Lewis and Fisher rats were usedEach weighs about 150 grams. Within the first three days of giving large doses of THC, about 95% of the population died.

Each of the compounds used contain about 225-3600 mg/kg THC. This is equivalent to a rat receiving up to 33 mg of THC. Increasing the dose to about 1,800 mg/kg would mean that 540 mg of THC would be delivered to the test subject.

The participating scientists documented the cause of the rodents’ death as severe hypothermia and its associated effects. Severe organ damage was also observed in the post-mortem process. CME may have reduced levels of toxicity in mice induced by delta-8 and delta-9 compounds, but it was not sufficient to prevent mortality. This indicated the protective effects of the periphery of cannabinoids in cannabis. Even in humans, hypothermia is a common effect of THC.

Dogs

The beagle breed was used. The average age of the animals was 7-10 months, and their weight was about 6-13 kg.

For the experiment, some were given megadoses of about 65 to 2,000 mg/kg or THC, and the rest were given 5,000 mg/kg of CME. The publication revealed that the largest of those dogs consumed up to 26,000 mg. The mortality rate in these animals was significantly reduced compared to rodents. Only two died. The deaths were not from psychoactive compounds but from aspiration. The beagle choked on hashish that was given through a tube.

Monkeys

Rhesus monkeys were first given 131 to 3150 mg/kg of THC or 5,000 mg/kg of CME. None of the monkeys used died from this dose. The scientists then increased doses of THC to about 9,000 mg/kg in an effort to work out how much THC could kill primates. This still proved insufficient to kill the animals.

However, the animals were severely affected by the large amounts of THC that were administered. Expressed behavior changes that affects their mood. According to the researchers, many of these animals showed signs of depression, imbalance, drowsiness, lack of coordination, lethargy and a pronounced change in posture. About 90% of treated primates assumed a crouched position often facing the back of their cases, with their heads and hands between their legs.

Conclusion

The research describes the toxic effects of cannabis as observed in humans – from effects such as psychosis, paranoia, decreased motor skills and cognition, or clustered/closed reactions seen in monkeys. Although apes and humans have very similar DNA molecules, this is not enough to conclude that Humans cannot die from massive amounts of cannabis that is high in THC.

Grow guide for marijuana beginners.
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