between several Psychological health Circumstances Being investigated for its relationship to the endocannabinoid system, autism spectrum disorder may be among the most intriguing. For years, researchers have studied the treatment of autism symptoms with Convention on Biological Diversity and other cannabinoids. They investigated the many clear links between autism and various aspects of the function of the endocannabinoid system.
Although the field is still relatively young, some key points have already been identified. a reconsidering The publication concluded in May 2021 that “cannabis and cannabis may have promising effects in the treatment of symptoms related to autism spectrum disorder, and may be used as a therapeutic alternative in relieving those symptoms.”
One month later, an article was published in Autism Research Describes a study in which male and female mice lacked CB1 Cannabinoid receptors have been analyzed for their social behavior and communication, two major areas of autism spectrum disorder (ASD). The researchers noted that these “mutant” mice spoke and behaved differently than normal mice.
“Our results show that loss of this receptor leads to many changes in social behavior and communication during early development and into adulthood, thus supporting a role for the endocannabinoid system in these ASDcore behavioral domains,” the authors concluded.
CBDV: towards the neurotype
More than two dozen other papers have been published on autism and cannabis or cannabis this year. In July, the magazine molecular autism Provided evidence that the administration of cannabidivarin (CBDV), a propyl isotope of Convention on Biological Diversity Also found in the cannabis plant, it can modify functional connectivity in the striatum towards a ‘neurotype’.
The striatum is a part of the basal ganglia that plays a central role during development. Previous search of the same thing United kingdom– And weThe resident authors demonstrated that both Convention on Biological Diversity And CBDV It affects brain function in the basal ganglia differently between those with an autism spectrum disorder versus those without an autism spectrum disorder.
The new paper extends this correlation even further to functional connectivity, a measure of correlates in brain activity that can be assessed via functional magnetic resonance imaging (fMRI). Atypical functional connectivity in the striatum may contribute to pluralism ASD The authors explain.
Future studies could bring science one step closer to the real world by determining whether modulation of functional connectivity in the striatum is associated with a meaningful change in symptoms.
CBC & Bladder Cancer
Speaking of the so-called “minor” cannabis, a recent study in the magazine Molecules Highlights the potential clinical value of cannabis (CBC), an intriguing minor vegetable cannabinoid found in small amounts in many cannabis varieties.
Researchers in Israel aim to identify cannabis compounds and their combinations that represent cytotoxicity against urinary bladder cancer, the most common type of urinary tract cancer. Using a test to test different cannabis extracts for cytotoxicity and high-performance liquid chromatography to determine the chemical content of the extracts, the scientists determined that the most active extract contained CBC And THC.
Their preclinical results, published in January 2021, suggest that CBC And THC together as well Convention on Biological Diversity on its own inhibitory cell migration and induced cell death in urothelial carcinoma cells.
rare cannabis plants
Hemp is not the only plant that contains beneficial cannabinoids. In a review article in the magazine the plantsIn India and Poland, researchers based in India and Poland write about the presence and biosynthesis of a wide range of lesser known phytocannabinoids in fungi (grifolic acid, cannaborsicromic acid), liverwort (lunolaric acid, phytatin), rhododendrons (durichromic acid, rhododorechromic acid), and flowering plants in genera Glycyrrhiza and Helichrysum (amorfrutin, bibenzyl-CBG).
Although they occur naturally in only small amounts, these cannabinoids are known to help plants relieve abiotic stresses such as cold, heat, excessive light and UV radiation, and to protect them from pathogens and eating, the authors wrote. Since these compounds also possess therapeutic, antibacterial, and antimicrobial properties, they are likely to be useful in treating human diseases.
The authors conclude that a better understanding of their natural structure in plants may provide insight into how these compounds can be replicated and produced on a scale sufficient for clinical use.
Nate Seltenrich, a freelance science journalist based in the San Francisco Bay Area, covers a wide range of topics including environmental health, neuroscience, and pharmacology.
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