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Monday, September 26, 2022

Antivirus hype is spreading fast – CBD Project

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A study posted last week in Natural Products Magazine It sparked a flurry of headlines declaring that cannabis can prevent or treat Corona virus disease, such a breathless ditty of Hey ho! finance: “It is also related to cannabis Corona virus disease Prevention, how can you invest in windfall? ” The project Convention on Biological Diversity asked the scientist Matt Elms, who has a Ph.D. and a postdoc work He focused on the biochemistry of cannabis, to assess the significance of this new research, which did not include humans or laboratory animals.

The project Convention on Biological Diversity: What do you think of the new study by researchers from Oregon State University and Oregon Health & Science University, which showed that CBD (CBDA, plant precursor Convention on Biological Diversity), and other acidic cannabinoids (CBGA And THCACan the coronavirus be stopped from infecting human cells?

Elmes: I have seen a lot of excitement generated in the media and social media about this new CBDA publishing. I think it really needs to be lightened up. The data in this paper come exclusively from test tubes and Petri dishes for cultured cells. We always need to be careful not to draw clinical conclusions from preclinical trials like this because almost every time there will be significant caveats when trying to translate them into a real-world setting.

The project Convention on Biological Diversity: Aside from the limitations of in vitro research, what is the substance of these findings?

Elmes: Honestly, the data doesn’t look particularly exciting to me. They showed that hemp acid can bind to the viral spike protein with micromolar affinities. These are concentrations that are too high to achieve in humans! It is a challenge to go beyond the nanoscale in most tissues, which makes me even more doubt that this will have real clinical applications. However, the intriguing “test tube” discovery remains that warrants further study to see if cannabis may be beneficial. Corona virus disease Beyond just its immunological effects.

The project Convention on Biological Diversity: Explain what you mean when you say that it is difficult to achieve high concentrations of cannabinoids in humans.

Elmes: The main conclusion of this research publication is that CBDA can comment on (has an affinity for) Corona virus disease spike protein, along with some proof-of-concept experiments showing that the presence of this cannabinoid on virus particles may hinder its ability to infect new cells. The weaker the strength of what scientists refer to as a binding-to-receptor interaction, the more of that bond you need to have an effect. In this case, CBDA He recruits and Corona virus disease Spike Protein is the future. This is why scientists define and describe the strength of ligand-receptor interactions in terms of concentration. We describe the concentration of interconnection required to achieve a significant amount of interaction with the future.

The project Convention on Biological Diversity: What are “micromolar joins”?

A “small molarity” (or molarity) is simply an expression for a concentration that depicts the number of molecules of a given compound per liter. The group behind this research experimentally found that CBDA It must be present in micromolar concentrations in order to do an appreciable amount of viral skeletal protein capture. When we consume cannabis, its analogs spread throughout the blood and fatty tissues of our bodies. Likewise half the concentration of cannabinoids that ends up in a tissue in terms of molarity. The data in this new paper shows that we will need to collect enough molecules of CBDA Each volume of tissue falls into the “micromolar concentration range” before we would expect it to have an effect. Most human tissues will not reach above the nanoscale concentration range (which is 1,000 times smaller than a micromolar) even when taking large doses of cannabinoids regularly! Thus, I think it is likely that the interaction that this group found is between citrus cannabinoids and Corona virus disease It would prove too weak to show much, if any, clinical relevance.

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