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Wednesday, October 5, 2022

Treating pets with medical cannabis

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Dr.. Gary Richter and Trina Shake, founders of the Veterinary Cannabis Association (VCS), speak on the board in American Holistic Veterinary Association conference in Reno, NVin October 2021. Below are excerpts from their question & answer session.

an introduction: “a task VCSIn his opening remarks, Dr. Gary Richter explained, “It is educating veterinarians and pet parents on how to use cannabis safely and effectively. We are working with regulators and lawmakers to sort through the myriad of legal issues currently facing the veterinary profession with cannabis. This is true for both cannabis Convention on Biological Diversity Products, but also up THC Hemp products if you live in a country where this type of thing is legal. the VCS It works with industry to ensure that products marketed and sold to animals are done correctly, are manufactured safely, and that product labeling and advertising is legal and appropriate. Finally, the VCS Working on product certification. So, for example, if you are going to choose a product that contains VCS Seal it and you’ll know this product has already been tested for quality and efficacy.”

Question from the audience: What will determine your rating system for products regardless of what hermit [National Animal Supplement Council] Do?

Dr. Gary Richter: We are actually consulting with a couple of people, including hermit, for potential collaboration when it comes to cannabis related products! So, really – hermit He does an excellent job of evaluating products and their manufacturing practices and that kind of thing. The flip side of that, what we’re going to bring to the table, is going to be the educational aspect as well. So, we can provide veterinarians and the pet owner with what is out there in terms of applications for specific cannabinoid ratios, terpene profiles, and what have you, so that people are better able to choose a formula that specifically serves whatever they want and treat.

Question: I was under the impression that you can not give THC For dogs and cats because it is toxic.

Dr.. Trina Hazaa: when THC Appropriate doses can be very effective. As an oncologist, many of my patients with cancer have been receiving very high doses of THCsometimes 30 mg or more of THC Twice a day. And that sounds crazy, right. If some people take this dose, they will be asleep for a week. But there really is an art to getting vets up to those higher doses. Not every pet can tolerate the same dose or titration schedule. As we increase the dose over time, the CB1 Receptors actually internalize, tolerance occurs. So, you can actually get the patient up to larger amounts of THC When calibrated with appropriate guidelines.

Question: Is cannabis effective in treating seizures in dogs and cats?

Dr.. Hazaa: There is some evidence for that THC It can be fairly effective in seizures – mostly by inhibiting the excitatory neurotransmitter glutamate, it can do so by binding to that CB1 receptors, which can block the continuous release of glutamate. But most of the research has been done Convention on Biological DiversityDominant products, or even Convention on Biological Diversity Isolates are very effective in seizures. So often, if you’re going to get any of them THC, it is possible that a low amount in a confiscated product. As we know, there is an entourage effect, which is really a description of the synergistic effect of all the different cannabinoids, terpenes, and flavonoids that are inside the product. There are other cannabinoids and a few terpenes that have been shown to help calm the nervous system and have anticonvulsant activity.

A randomized, blinded, controlled clinical trial has been published showing that dogs with epilepsy have received a Convention on Biological DiversityThe cannabis-derived product reduced the average frequency of monthly attacks compared to the placebo group.

Dr.. Richter: Can you use cannabis as a standalone seizure control? For the most part this was not my experience. I will tell you that I have patients who take anti-epileptic drugs and I have other patients who just take cannabis, herbs, acupuncture, etc. It is clear that each seizure patient is unique to them and how they respond.

Question: Can we talk about different proportions of hemp and hemp acids? What are the differences in effectiveness or benefit between THC And THCA And Convention on Biological Diversity And CBDA?

Dr.. Hazaa: Let’s start this discussion with some information about ratios and terms. a Convention on Biological DiversityA dominant product means there is more Convention on Biological Diversity From THC. It is usually a large amount of Convention on Biological Diversitywhen I say high, it’s usually 20 or 30: 1, which is 20 or 30 parts Convention on Biological Diversity for one part THC. These types of products are usually used for seizures, certain types of cancer, anxiety, and mild to moderate inflammation/arthritis. Convention on Biological Diversity He has more than 65 targets, so he doesn’t just aim CB1And CB2 receptors like THC Mostly it targets many other receptors. This is why you see that these hemp-derived products work well and have been published to be effective for arthritis and seizures in dogs. There are some ideas that Convention on Biological DiversityDominant products may be effective as an antidiabetic because they can reduce blood sugar (some mouse models have been shown to do so).

A veterinary study of carcinoma cells in dogs has recently appeared CBDA And Convention on Biological DiversityAnd Convention on Biological Diversity It had more antitumor effect on five different cancer cell lines in canines than it did CBDA. But again, this is in a Petri dish and not in a patient. There are papers looking at THCA It has antiemetic, anticonvulsant and anti-inflammatory effects. It is unique in its anti-inflammatory effect because it inhibits TNF-Alpha that CBDA No, while CBDA May provide anti-inflammatory effects in part by not being selective Cox repression. CBG (Cannabitrol), seems to be the new fad of cannabis. Some people call it the mother of all cannabis. It really isn’t. it’s the mother CBGA It is the mother of all cannabinoids. CBG It is a very special molecule in that it has profound anti-tumor effects. This is where I think it will work its magic. Also, CBG Does it have muscle relaxing effects. So for pets with muscle tension from pain or even urethritis, I can see how effective a molecule can be.

Question: Can you talk about the bioavailability of the different forms, whether it’s in some treatments versus some drops or extracts.

Dr.. Richter: Convention on Biological Diversity It is permanently bioavailable. There are certainly some differences in how the products are packaged. For example, I think it was a Colorado State study that looked at nudes Convention on Biological Diversity Encapsulated in microcapsules Convention on Biological Diversity versus something that was applied topically. And that’s interesting because they got blood levels in all of them. In the end, if I remember correctly, the micro-capsule reached blood levels a little faster. But it was also eliminated a little faster than the nudes Convention on Biological Diversity. The topical type got there, but it took longer. [One study] It was found that the bioavailability was increased if it was given as a treatment or if you did not give it with a treatment, you gave it with a meal, compared to that given on an empty stomach, where the bioavailability was not very good. And it has been proven, they did it in monkey models, and they did it in humans as well, demonstrating that there is an increase in bioavailability when any cannabis product is given with a fatty meal. Most of the products you’ll find are in tincture form, so it’s not hard to put a little ball of peanut butter or something like that into it.

Question: What about sublingual products?

Dr.. Richter: A sublingual problem is just a practical problem in dogs or cats. When you talk about some cannabis products, you know that one of two things will happen when you put them under their tongue. Either they will hate it or they will love it and they will want to swallow it. One way or another, he won’t stay there for long. I think it’s just a practical matter.

Comment from the audience: I find thematic Convention on Biological Diversity On external wounds and precancerous things, I get data from my clients with maximum results, even with mast cell tumors…this is using only topical hemp products. I have pictures of a horse with a sarcoid tumor. I have people for topical donation and Convention on Biological Diversity oils. What I did was already drained and healed, choppy cuts each time, this tumor just started to heal in the horse’s ear.

picture

Dr.. Richter: Very cool.

Question: Are there differences in the treatment of cats and dogs with cannabis?

Dr.. Richter: I think the big difference between cannabis use in cats versus dogs is that dogs will display a very specific type of THC Intoxication, constant ataxia – this is not something you will see in a cat. For unknown reasons, dogs have a large number of CB1 The receptors are in their brainstem, more so than in humans, than in cats. However, cats can still get it THC Poisoning, but it will not appear exactly the same way. But I’ve had a lot of luck with cannabis in cats. I think they do a good job with it. I think if you get the formula right, so if you’re using a liquid, just use one or two drops because it’s concentrated enough. I find it works great and is well tolerated.


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