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Medical marijuana uses for mouth ulcers, genital pain, and spinal disorders

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In his 1978 song “The Bush Doctor,” Peter Tosh embraced the health benefits of marijuana by citing two diseases that might strangely strike some listeners: glaucoma and asthma. But Tosh was correct. Glaucoma was actually one of the first indications he used we The government provided packages of marijuana cigarettes to a handful of patients beginning in the late 1970s. Experiments around the same time showed that marijuana smoke can expand and open the airways – unlike tobacco smoke, which has the opposite effect.

If he were still alive today, Tosh would probably feel vindicated and admired by the incredible array of ailments he treats with cannabis and cannabis. Convention on Biological Diversity It has been scientifically supported in recent years. A larger number are currently being investigated—and others, at least, are still being investigated for involvement of the endocannabinoid system.

As for Tosh, his 1976 anthem “Legitimating It” also praised the pot as a cure for influenza, tuberculosis, and a vague (though rhyming) condition called “nomara clot.” We may never really get to what he meant by that, but here are three recent research papers in medical journals in the field on the mysterious or unexpected therapeutic applications of cannabinoids and cannabinoids.

Convention on Biological Diversity Mouth ulcers treatment

Researchers in China wanted to know if treating mouth ulcers was among its many potential uses Convention on Biological Diversity. To find out, they tested a file Convention on Biological DiversityOral spray in three different concentrations (0, 1, 10 mg/ml) on tongue ulcers in mice over three days. Their results were published this month in a newspaper Dental Research JournalAnd the1 Indicate that not only Convention on Biological DiversityTreated mice generally recover faster than control animals, but higher doses Convention on Biological Diversity The group tended to do better than the lower dose group.

The researchers also investigated the mechanisms behind this effect. They determined that it is largely attributable to the immune response and inflammatory pathways mediated by direct activation of PPARNuclear receptors, a major target of Convention on Biological Diversityand, to a lesser extent, partial activation of CB1 receptors. This work was funded in part by a China-based pharmaceutical company.

Endocanabinoids for the treatment of female pain

Cannabis is well known for its ability to fight pain and inflammation. So researchers in the Department of Obstetrics and Gynecology at Johns Hopkins School of Medicine (with practice OB/Gene As first author) a systematic review of existing studies on cannabis use in gynecological pain conditions. These include chronic pelvic pain, which is said to affect one in four women worldwide;2 Dysmenorrhoea. Vulvar pain. Endometrial. interstitial cystitis (bladder pain syndrome); and gynecological malignancies.

Sixteen studies met the inclusion criteria for the review, which were published this month in the journal Obstetrics and Gynecology3 It was covered in the February episode of the magazine audio notation. Two randomized trials and six prospective cohort studies evaluated the efficacy of drugs containing either palmitoylethanolamide (PEAan endocannabinoid-like compound) or an inhibitor of fatty acid amide hydrolase (FAAH which is an enzyme that degrades PEA and endocannabinoids), while eight cross-sectional studies evaluated cannabis use.

“Survey data showed that most women reported that cannabis improves pain from several gynecological conditions,” the authors wrote. Cohort Studies and RCT Utilization PEA-Combined medications reported reducing pain.” Although these results are promising, they come with several of the usual caveats: “Interpretation of studies is limited due to differing cannabis formulations, delivery methods, and dosages that preclude a definitive statement on cannabis for female pain relief.”

Cannabis for spine disorders

Also published in February 2022, a new research paper in the journal Current reviews in musculoskeletal medicine4 It summarizes recent research on the use of cannabis and cannabis in four contexts of “spine disorders”: Chronic low back pain. spinal cord injury; Before and after surgery and general orthopedic procedures. The narrative review identifies the major studies and papers in each of these areas and provides an overview of their findings regarding various factors, including pain, spasticity, recovery from surgery, and opioid use.

Long and Short: Evidence for the use of cannabis for spinal disorders is still limited and generally low quality but contains some promising nuggets.

Senior author and orthopedic surgeon at Northwestern University Srikanth Devi said in an email to Project Convention on Biological Diversity.

“Before we routinely recommend it to patients undergoing surgery, we need to know its biological effects on spinal fusion and long-term complications. This will require robust prospective studies. For the time being, for patients who say they are getting good rest. Convention on Biological Diversity or THC Products that are not surgical candidates, I think, may be an effective alternative treatment.”

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