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Exercise and the endocannabinoid system

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Once researchers began noticing in early 2000s As circulating endocannabinoid levels in the human body become elevated during exercise, the term “runner’s high” has gained new meaning. According to a 2004 article in Runner’s world By then, experts were already questioning the old endorphin model and starting to get around to cannabinoids, specifically anandamide, which, THCis associated with CB1 future and like too THCIt has analgesic (painkilling) and excitatory effects.

But the matter is not resolved yet. Research into the source of the highly antagonistic and subtle role of the endocannabinoid system (ECS) Continue well through 2010s. And although the underlying mechanisms and effects of endocannabinoid production during exercise are widely accepted today, deeper aspects of this association are still being researched — addressing the Effects of cannabis use For athletic performance, the relationships between THC Intake and exercise motivation, and other aspects of ECS Job. After all, with exercise affecting systems throughout the body including heart and respiratory rates, metabolism, and cognition, this “master regulator” is bound to be involved.

Runner height review

Just a few months ago, a magazine aimed at healthcare professionals was called neuroscientist He published a review titled Skeptical, “Do Endocannabinoids Cause Hostility High? Evidence and Open Questions.”1 Spoiler alert: Yes, they do. “Exercise-induced increases in endocannabinoids appear to be associated with traits of elevated runners, i.e. lower levels of anxiety and increased euphoria… [and] Decreased pain sensation after exercise,” the Germany-based authors wrote.

The article ends with “An interesting recipe to stimulate the release of endocannabinoid in laboratory conditions.” He notes that “running appears to be the best way to increase endocannabinoid levels in the blood, followed by cycling” and that “the duration should be at least 20 minutes to achieve anxiolytic, analgesic, and positive mood effects.” The authors also note that the highest positive mood effects can be expected 30 to 35 minutes after exercise.

Exercise and ECS

Paper published in December 2021 in Hemp and hemp research2 It helps to further solidify decades of evidence about the effects of exercise on circulating endocannabinoid levels through a first-domain meta-analysis, or statistical synthesis of the results of previous studies.

Researchers at Wayne State University (Michigan), Washington State University, the University of Texas at Austin and the University of Calgary began by examining a total of 262 articles, 33 of which met the criteria for inclusion in a systematic review. Of these, ten contained sufficient data to be included in the meta-analysis, confirming a “steady increase in both AEA and 2-AG [the other primary endocannabinoid] After acute exercise across methods (eg, running, cycling) and species (eg, humans and mice), and in people with or without pre-existing health conditions (eg, Post Traumatic Stress Disorderdepression).

Besides confirming these general trends, the meta-analysis also showed some inconsistencies. “There was significant variation in effect size across studies, which may relate to exercise intensity, fitness, timing of measurement, and/or fasting status,” the authors wrote. The effects of chronic or long-term exercise on circulating endocannabinoids have also been inconsistent, reinforcing the notion that temporally elevated levels during exercise are associated with a transient, sometimes ethereal ‘runner’s high’.

Convention on Biological DiversityPhysiology and “Bioenergetics”

Unlike anandamide and THCAnd Convention on Biological Diversity not related to CB1 receptors. So it is unlikely to have a significant effect on runner’s height. But considering the indirect interactions of CBD with both CB1 And CB2activity at a variety of other receptors, and a wide range of known physiological effects — including counteracting pain, inflammation, and stress — one might assume could somehow affect the body during exercise.
According to the results of a randomized controlled pilot study published in March 2022 in the journal sports medicineAnd3 It is – although the exact nature of this effect remains uncertain. Because of the small effect sizes among a group of only nine endurance-trained athletes, the researchers were unable to draw any clear conclusions.

without compromising performance,”Convention on Biological Diversity It appears to alter some of the key physiological and psychological responses to aerobic exercise,” they wrote — including feelings of pleasure during exercise, exercise-induced inflammation, and VO2 And VO2Maximum, measures the amount of oxygen the body can use during exercise. “Larger studies are needed to confirm and better understand these initial findings.”

Physical activity, and ECS metabolic health

Moving beyond the level of runner’s, a recent third review points to the role of the endocannabinoid system as a mediator of the metabolic health benefits of exercise. Or, to look at it another way, the paper published by Polish researchers in International Journal of Molecular Sciences (March 2022),4 It begins by attributing insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and other signs of metabolic imbalance to dysregulation of the endocannabinoid system that can be corrected through exercise.

While the individual links in this chain are supported by existing scientific evidence, “the data show a direct link between ECS Also, physical activity in the metabolic health aspect is very rare,” the authors wrote. Their paper seeks to summarize the current state of knowledge supporting targeting targeting. ECS Through physical exercise to treat and prevent metabolic disorders. It is an interesting academic exercise that can refer to regimens of exercises designed to treat these harmful and increasingly prevalent conditions.

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