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CBD and THC for traumatic brain injury

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This is an excerpt from The essential guide to Convention on Biological Diversity By Editors at Reader’s Digest and Project Convention on Biological Diversity.

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Brain injury (TBI) is one of the leading causes of death worldwide in people under 45 years of age.1 Many who survive severe head injuries have permanent behavioral and neurological impairment that negatively affects learning and memory and often requires long-term rehabilitation. An estimated 5.3 million Americans live with a TBIAssociated disability.2 Even the so-called mild cases TBI It can lead to post-traumatic stress episodes, impaired brain function, and reduced life expectancy. People can also have an acquired or non-traumatic injury, such as in the case of a stroke, which causes similar damage to the brain due to internal factors such as lack of blood flow and oxygen (ischemia).

hemp like THC And Convention on Biological Diversity May reduce trauma and symptoms after brain injury thanks to its positive interaction with the endocannabinoid system (ECS). 2011 article in British Journal of Pharmacology Describe ECS As a “self-protection mechanism” that goes into high alert in response to a stroke or TBI. The article was co-authored by the Israeli scientist Raphael Meshulam, and the article notes that endocannabinoid levels in the brain increase significantly during and after TBI. These endogenous compounds are activated CB1 And CB2 receptors that protect against TBINeurological and motor deficits.3

By manipulating the endocannabinoid system with cannabinoids, medical scientists have been able to reduce brain damage and improve functional recovery in animal studies of stroke and TBI.4 According to a 2010 report in British Journal of PharmacologyAnd Convention on Biological Diversity It can limit the amount of damaged tissue and help normalize heart rhythm disturbances such as arrhythmias common after closed head injury.5And6

The damaged brain can be noticeably plastic, but there is only a limited chance – generally thought to be anywhere from 10 to 60 minutes7 For therapeutic intervention to prevent, mitigate or delay the degenerative domino effect of brain cell death and protective blood-brain barrier damage that occurs during the secondary injury cascade (a wave of additional damage that occurs as a result of reduced blood flow to the brain after the primary injury).8Convention on Biological Diversity Expand that window of opportunity. Researchers have learned that Convention on Biological Diversity It can impart potent, long-lasting neuroprotection if administered shortly before or shortly after the onset of ischemia.9

In 2016, scientists at the University of Nottingham (United kingdomA report has been written Convention on Biological Diversity The protective blood-brain barrier protects against the harmful effects of a lack of oxygen and fuel after an injury.10Convention on Biological Diversity The blood-brain barrier prevents damage and becomes more permeable through 5-activation.HT1A serotonin and . receptors PPARNuclear gamma receptors.11Convention on Biological Diversity It also protects the brain by increasing the concentration of endocannabinoids in the brain.

Researchers at the University of Nottingham also conducted animal or preclinical laboratory research that examined the anti-inflammatory and neuroprotective effects of CBD (CBDA), the raw, unheated version of Convention on Biological Diversity It is found in the hemp plant. “Like Convention on Biological DiversityThe researchers concluded:CBDA Effective in reducing blood permeability and inflammation in a cellular model of stroke. ” Convention on Biological Diversity And CBDA Both restore the integrity of the blood-brain barrier by activating 5HT1A Serotonin receptors, which mediate Convention on Biological Diversity‘sand CBDAIts anti-inflammatory effects.12

Many athletes claim that Convention on Biological Diversity It can help relieve the chronic neurological problems associated with chronic traumatic encephalopathy (CTE).CTE), which is a very dangerous form of TBI Due to the accumulation of numerous concussions.13CTE It increases the risk of neurological problems later in life and speeds the progression of dementia. anecdotal benefits Convention on Biological DiversityRich hemp oil CTE They are well known among soccer players, boxers and other professional athletes who are prone to head injuries.

project Convention on Biological DiversityA 2019 survey found that among people who use Convention on Biological Diversity for a brain injury, Convention on Biological Diversity Proven to relieve headaches, irritability and agitation. Convention on Biological Diversity It was less helpful for balance issues. In a small percentage of the participants, Convention on Biological Diversity It appears to make problems with memory, concentration, and self-expression worse, but it is unclear if this is a consequence Convention on Biological Diversity or THC Or if there are other unknown factors at work.

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