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Monday, February 6, 2023

Take it slowly with GABA

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“Wise and slow; they stumble and they run fast.” – Shakespeare, Romeo and Juliet

As you can see in my daughter’s favorite cartoon based on Aesop’s “The Tortoise and the Hare,” the race is going slowly and steadily. This rhythm fits japa like that. and while japa Not one of the excitatory neurotransmitters you see in the popular press, it has to be.

Not as specialized as the more well-known messenger molecules such as serotonin, oxytocin or dopamine, japa It is the primary inhibitory neurotransmitter in the brain.

They tortoise your neurons, the blinking red light of their synapses, your brain’s signal to calm their firing. Officially known as γ-Aminobutyric acid, japaIts main function in the central nervous system is to reduce the excitability of neurons.

The brain needs balance because excessive excitement can be harmful. It is one of the most important aspects of neuronal health. When the clamps flare up too often and too often, they get as hot as an engine without oil. Toxicity is called excitation, and it occurs most commonly in major neurodegenerative diseases as well as strokes, epilepsy, traumatic brain injury, alcohol use disorder, and rapid withdrawal from benzodiazepines. Excitatory toxicity is often caused by unhealthy levels of glutamate – the brain’s primary excitatory neurotransmitter (subject Previous article in this series) and yang’s japaYin.

In a fitting twist of fate, japa It is made from glutamate. From the great excitatory neurotransmitter comes the great inhibitory neurotransmitter. And working together, they both act as vassals that facilitate the functions of our endocannabinoid system (ECS).

japa and the ECS

Do you know where more CB1 Are there cannabinoid receptors? The same CB1 receptors that THC Used to take you high? Most of these famous people CB1 Receptors are embedded in your brain japa– Production of interneurons.

interstitial nerves – Also known as staging neurons, conductive neurons, or intermediate neurons – they connect to small circuits in local areas of the brain (in addition to connecting different brain regions). They act as the critical mediator between sensory input entering the body and the response to motor signals that are sent out.

as you see in This graph, the traditional function of interneurons is to insert themselves into a circuit and, if activated, compress the signal. in technical languageAnd the japaergic interneurons’ gate signal flow and network dynamics determination [and] Necessary for shaping network responses. Through their inhibitory actions, endogenous neurons prevent instability in the brain. And when they activate a coil CB1 future, the most likely response is to release the interneuron from japawhich does a lot of the work he does ECS.

While the “neurotransmitter recognition” profile focuses on japaHigh-level neural processes, we should not overlook the importance japaHis role in other areas such as:

Anxiety, benzos, and Convention on Biological Diversity

One theory about anxiety is that it is the result of inadequate inhibitory control in the brain. In this context, the use of benzodiazepines (eg Valium or Xanax) to increase inhibition makes sense. Rather than direct activation of a receptor such as a switch that turns the lock, the mechanism of action of benzos is a “positive allosteric modulation” (signal enhancement) of japafuture.

benzos Positive modifiers From japa. So are barbiturates (the first generation of kitties), the euphoric Quaaludes (which a certain generation is interested in), and the archaic man’s favorite alcohol. Strengthening japa Through these drugs it leads to dissociative and sedative effects that can be terribly enjoyable and addictive.

Benzos isn’t a big company just because of the big advertising budgets. As powerful anxiolytic (anxiolytic) agents, they are highly effective – and have a high potential for risk. An overdose, either alone or with wine, can be fatal. The effects of benzene withdrawal can also be fatal if they are stopped too quickly without diminishing.

According to 2019 Canadian studyWhen patients received a prescription for cannabis, half of them discontinued their benzo prescriptions. 2020 Article review On neurological diseases that the cannabis plant may help restore a fracture japa transportation system. The cannabis plant, in particular Convention on Biological DiversityIt is known for its calming effect. In large part, this may be due to its control by the endocannabinoid system japa And calm the brain.

in mice stressed By restricting them (they hate this), the endocannabinoid system helped calm their racing heart through japa – And if you block them CB1 Cannabis receptors out of action, their hearts quickened even more. in another place animal studySpanish scientists sought to explore how to do this Convention on Biological Diversity It exerts its anti-anxiety effects. They found it in mice with no CB1 receptors Convention on Biological Diversity Stop working for worry. They also found that the presence of Convention on Biological Diversity levels decreased CB1 receptors japaA receptor in the amygdala (the fear center in the brain), while increasing CB2 receptor levels.

It’s tempting to speculate Convention on Biological Diversity regulate, directly or indirectly, japaIt is a neurotransmitter.” This observation agrees with Previous results From Australian investigators, who reported that Convention on Biological Diversity The endocannabinoid 2-AG Both interact with japaFuture in a way that enhances the natural calming effects of japaslow neurotransmitter.

Your beautiful smart brain


japaThe inhibitory effects can help your brain to be smarter as it heads toward the sweet spot of healthy, moderate activation. In this neuronal balance, your Watch out for this The function is no less important than sHighest bother to note it. To stop getting out of control from overstimulation, it is essential that the brain ignore signals that are no longer perceived as dangerous or relevant.

It turns out that a file Combination of dopamine and endocannabinoids to organize japa– The firing of synapses in the rat’s prefrontal cortex (the highest area of ​​the brain), leading to what scientists refer to as “long-term depression” or Ltd.. This is a shortcut for your brain’s ability to reduce circuit activity after activating it multiple times. This reduction can last for hours or more. It’s the downside of synaptic plasticity, the ability to lower the signal level so you can upgrade it again if necessary. Otherwise, your brain will max out by firing all of your circuits all the time.

In addition to protecting the brain from excitatory toxicity, the inhibitory effects of japa Affect learning and memory. In the mouse memory model, the ability of certain serotonin receptors to regulate spatial memory depends on: track includes CB1 And the japa. In another curiosity studysignals japa Speeds up the breakdown of endocannabinoids, which leads to “learning-induced metaplasia.” This means that your brain’s ability to adapt and change comes, at least in part, through endocannabinoids and japa.

In the olfactory bulb (the location of your sense of smell), endocannabinoids modulate japasynapses. And at the tasting center of your insulated shell, the CB1 mediating the future japaplasticity for your learning system. It is the endocannabinoids that regulate both japa and glutamate in the diagramAn area of ​​the brain associated with habit formation and movement control. capacity CB1 A future for helping mice be social and exploratory based on sensitivity Balance between glutamate and japa.

The japa health files

For specific disease-related conditions japa Dysfunction, let’s take a slow and deep science tour through japa garden. As always, more clinical research is needed, but for anyone with these indications or areas of interest, it’s relatively easy to start harnessing the power of japa and the ECS to improve your health.

  • ALS: In a mouse model of amyotrophic lateral sclerosis, CB1 The future showed the ability to exercise a very good level of control over Both signal transmission japa and glutamate.
  • Autism: According to this brain imaging study of humans, both Convention on Biological Diversity And the CBDV Helps with autism japa and glutamate pathways.
  • Circadian rhythms: In the circadian rhythm section of your brain, cannabis signals cause their effects by “recruiting” astrocytes (the brain’s specialized immune cells) via adenosine and japa transition.
  • Down’s syndrome: In a mouse model of Down syndrome, CB1 levels regulator on japa nervous cells and downregulated on glutamate neurons.
  • eyes: In the rat eyesAnd the CB1 Activation helped fine-tune visual cues by adjusting japa.
  • Exercise and food: in mice, CB1 The receptors enhance exercise activity and reduce the craving for food japa nervous cells.
  • Huntington’s disease: In humans, Huntington’s disease alters cannabis And the japa receptors. In the mouse model, the . level is CB1 on the receptors japa Nerve cells sink.
  • Pain: In the rat model of pain, a synthetic cannabinoid induced analgesia Across japaa. in mice, Convention on Biological Diversity Pain relief by inhibition japa Work potential In the gray periocular (a region of the midbrain that integrates behavioral responses to internal stressors such as pain, as well as external stresses such as threats). In mice with nerve injuries, CB1 Levels rise in the cortex and activate CB1 The receptors cause pain relief by japa interstitial nerves. In mice, females felt more pain relief CB1 Activation is more than males because females have more japa– neuron production with CB1 receptors In the relevant brain region. In rats with arthritis, the treatment combination of stem cell injections, endurance training (mini treadmills) and ozone therapy (I suppose they went to Los Angeles For this) the pain is decreased by CB1 And the japa receptors.
  • Maturity: In mice, insulin Increases japa transition In neurons that release a hormone associated with puberty via the endocannabinoid system.
  • schizophrenia: In a rat model of schizophrenia, Convention on Biological Diversity cannabis recovery japa signal deficiency.
  • Sleeps: The CB1 The receptor helps partially control sleep Across japa.

Lex Pilger writes articles on psychotropic and graphic novels about the endocannabinoid system. publishes a weekly newsletter on cannabis cannabis & People and behave 1 over 1 educational sessions to use Convention on Biological DiversityAnd the PEAAnd the THC & CBDA for serious health conditions.


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