PubMed: Citrus cannabis inhibits proinflammatory cytokine release by blocking entry of store-activated calcium

Occupation (OCV). 2022 Jul 8; 3 (4): zqac033. doi: 10.1093/post/zqac033. Collection 2022.

Abstract

cannabis It has long been known that it affects many biological activities. Although plant extracts, purified cannabis, or synthetic cannabinoids analogs have shown therapeutic potential in pain, inflammation, seizure disorders, appetite stimulation, muscle spasm, and treatment of nausea/vomiting, the underlying mechanisms of action remain undetermined. In this study, we present the first comprehensive overview of the effects of the whole plant cannabis Various pure hemp extracts and store-run calcium (Ca .)²⁺) Entry (SOCE) in many different immune cell lines. It is running in storage Ca²⁺ Entry is one of the most important Ca²⁺ Flow mechanisms in immune cells, which are essential for T-lymphocyte activation, triggering the release of proinflammatory cytokines and mediating inflammation and T-cell proliferation, mechanisms essential for the maintenance of chronic pain. Whereas the two main cannabinoids are cannabidiol and trans-Δ⁹THC was largely ineffective in inhibiting SOCE, we reported for the first time that several small cannabinoids, especially carboxylic acid derivatives and especially cannabisolic acid, showed high efficacy against SOCE by blocking calcium currents that activate calcium release. Furthermore, we showed that this inhibition of SOCE resulted in decreased nuclear factor to activate active T cells and production of interleukin-2 in human T lymphocytes. Taken together, these results suggest that cannabinoid-mediated inhibition of a proinflammatory target such as SOCE may at least partially explain the anti-inflammatory and analgesic effects of cannabis.

PMID:35910331 | PMC:PMC9334010 | DOI:10.1093/job/zqac033