Hemp has a lot of industrial applications, and although some consumers may tout the benefits of taking cannabis for constipation, high cholesterol, eczema, arthritis, and other conditions, the evidence supporting these uses is still limited. However, new preclinical data suggest this chopsticks The structures contain some of the essential helpers for your intestines.
The preclinical data, published in peer review, was announced by brightside biological sciences and artificial intelligence company Journal of Nutritional Bioactivities, last week. The results show that two of the bioactive compounds found in cannabis hulls – N-trans caffeoyltyramine (NCT) and N-trans feruloyltyramine (NFT) – have the potential to support gut barrier function.
Cannabis link to gut health
A bioactive compound is a type of chemical found in foods such as fruits, vegetables, nuts, oils, and whole grains that have actions within the body that can promote good health. These compounds are often studied for their ability to prevent disease. While science has known that bioactives can have a critical impact on our health, the vast majority of bioactive compounds are still unknown, and some call them the “dark matter of nutrition.”
Gut health is linked to the immune system, central nervous system, and intestinal tract. Therefore, it can be linked to the general health of the body. The gut barrier allows the body to absorb essential nutrients and immune sensing, while still restricting pathogenic particles, toxins, and bacteria. When the intestinal epithelium is more absorbent and easily porous, referred to as ‘leaky gut’, this can be a symptom of poor gut health.
During this in vitro study, which used Brightseed’s Forager AI platform, proliferating human colonic transverse epithelial cells were seeded and co-cultured with tumor necrosis factor (TNF) combined with NCT, NFT, or NCT/NFT over a 48-hour period. The authors reported that addition of TNF caused a decrease in transepithelial electrical resistance (TEER) and an increase in intestinal permeability, leaky gut symptoms, while combined administration of NCT and NFT caused a dose-dependent and statistically significant reversal of TEER and intestinal impairment. permeability.
Jim Flatt, CEO and co-founder of Brightseed, said: press release. “These insights into how NCT and NFT can support gut function, specifically the strength of the gut barrier by restoring a healthy epithelial barrier, provide a solid foundation for ongoing clinical research to demonstrate the benefits of natural ingredients for personalized and proactive health solutions.”
Using artificial intelligence to detect bioactive compounds
Brightseed’s Forager has determined the activity of the two bioactive compounds on a key biological receptor that controls gut health. NCT and NFT have also been shown to act as agonists of the HNF4a protein, which when expressed in the gut associated with a high-fat diet can be associated with poor gut health and reduced gut barrier integrity.
The botanist scoured the plant kingdom in search of new sources of these two bioactive compounds and identified hemp lignans as one of the richest sources. Last fall, Brightseed launched Brightened Bio 01It is a food and beverage hemp fiber that contains NCT and NFT to support intestinal strength and intestinal lining that maintains healthy intestinal barrier function. Hemp fiber is formulated to optimize the bioactive content while retaining the fiber and nutrients found in hemp and intended for use in cereals, granola, nutrition bars, functional drinks, and more.
Sofia Elizondo, COO and Co-Founder of Brightseed, is similarly excited that Brightseed looks forward to continuing similar ideas, in developing “a range of bioactive ingredients to address important areas of consumer health.”
“Brightseed’s focus on computational biodiscovery coupled with advanced metabolomics science enables the food, beverage and functional nutritional supplement industries to unlock the full potential of activities vital to human health,” added Elizondo.