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Sunday, March 26, 2023

Rest in peace Raphael Meshulam

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Raphael Meshulam, the godfather of cannabis research, is passing away

Here are the top 5 contributions to marijuana as we know it today

In our cannabis world Search for thanks. It is through the hard work and efforts of people all over the world who have spent time and resources studying cannabis and its health benefits. Because of the research, we know what cannabinoids are good for and how they work in the human body.

However, no one else has done more cannabis research than Dr.. Raphael Meshulam. An Israeli chemist, researcher and professor of medicinal chemistry has devoted a large part of his life to the study of marijuana. So much so that he got the nickname, “The Godfather of Cannabis Research” early on. In 2016, his efforts were recognized and he was subsequently awarded a Lifetime Achievement Award at Cambridge, due to several decades of advanced research. This is just one of the many awards he received during his lifetime.

Unfortunately, he just passed away at the age of 92. In honor of Dr. Meshulam, learn about his most important contributions to cannabis research:

  • Isolation of THC for the first time in history: During the early years of his research in 1963, Dr. Meshulam and his team focused on understanding the chemistry of cannabinoids. It wasn’t long until they succeeded in doing so THC isolate (tetrahydrocannabinol), one of the two most popular cannabinoids in marijuana, and responsible for the plant’s psychoactive effects. After he isolated THC, they were able to understand the chemical structure of THC and eventually synthesize it.

isolation THC It was incredibly fundamental to tons of other cannabis research. Soon it became the most popular cannabis due to its height, but soon after, CBD (Cannabidiol) became equally popular for other equally important reasons.

  • Discovering the Entourage Effect: Dr. Meshulam discovered the entourage effect with Dr. Shimon Ben-Shabbat in 1999. It refers to the synergistic way in which cannabinoids work together, usually enhancing each other’s benefits when taken together rather than taken individually or in isolation. He and his team noticed that when some cannabinoids were taken by themselves, they had little to no effect yet when combined with THC or other cannabinoids, they were actually quite beneficial.

It is important to understand the influence of the surrounding elements Not just for scientific purposes today, but also to consumers. It can help medical patients better understand what kind of products they should consume. This is especially important because there are dozens of different forms of cannabis today, from CBD and THC isolates to whole plant medicine. People take isolates for certain reasons, although now because of the entourage effect, we know that if you want to maximize the healing properties of marijuana, it’s best to take a whole plant medicine instead.

  • Introducing the Benefits of CBD for Treating Epilepsy: In 1980, Dr. Mechoulam released the results of a small study he had studied whose results indicated that CBD could be beneficial in reducing seizures among patients with epilepsy. He found that CBD was more effective than a placebo, after which he expected interest from large pharmaceutical companies to develop CBD-based drugs for epilepsy.

It didn’t happen, at least for several more decades. Because of its revolutionary research, THC had to share the spotlight with CBD, which many people didn’t think was important at first – but it was. CBD doesn’t get you high, but it does seem to have powerful anti-epileptic properties that no other pharmaceutical drug has ever been able to beat.

Fast forward to current times, and now it’s easy to see that Dr. Meshulam was onto something big when he was studying CBD when no one else was paying attention. CBD is now a household name in cannabis, and is made into everything from beverages to capsules, cosmetics, food, and more. Thousands of people use CBD not only for epilepsy but also for anxiety, stress, depression, inflammation, and general well-being.

  • Discovery of endocannabinoids: Dr. Mechoulam’s research also led to the discovery of endocannabinoids, particularly anandamide in 1992, a compound produced in the human body capable of activating the CB1 receptor, the same receptor that binds to THC. This was a major breakthrough because it was the first endocannabinoid ever discovered.

His discovery of anandamide not only had a huge impact on cannabis research, but had far-reaching benefits for the world of biology, biochemistry, chemistry, medicine, and pharmacology as a whole.

  • Discover Cannabinoids More Powerful Than CBD and THC: Dr. Mechoulam hasn’t stopped working on his cannabis research. In 2020, discover something else A compound called EPM301, which has been found to be more powerful than THC and CBD. He was 88 years old when EPM301 was discovered.

It took a while EPM301 They are caught because of their instability, though Mechoulam came up with a way to modify the acids that allowed them to be stable long enough, allowing them to be used in further studies and experiments. In addition, they found that EPM301 could be helpful in treating nausea and anxiety, although there is a possibility that it could also help treat cancer, chemotherapy, psoriasis, and inflammatory bowel syndrome.


Dr. Meshulam is the only person on earth who has contributed a significant amount of breakthroughs to the cannabis industry, as well as to medicine and patients. Thanks to his lifelong work, we know more about cannabis than ever before and it has helped transform the lives of millions of people around the world.

doctor. Meshulam For a Nobel price, read on…

Rafi Masholm Noble Prize


Grow guide for marijuana beginners.
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